Clair L. Firth, Hanna Keppelmüller, Annemarie Käsbohrer, Alexandra Hund, Thomas Witte. Comparison of metrics to assess antibiotic use in small ruminants at a university referral clinic between 2005 and 2019.. 2023. agriXiv.2023.00192
DOI：10.31220/agriRxiv.2023.00192
声明：预印本系统所发表的论文仅用于最新科研成果的交流与共享，未经同行评议，因此不建议直接应用于指导生产实验。
Comparison of metrics to assess antibiotic use in small ruminants at a university referral clinic between 2005 and 2019.
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Abstract: Abstract Background: Monitoring antibiotic use is essential to provide a framework enabling veterinarians to use antibiotics prudently. Methods: Electronic medical records from the University of Veterinary Medicine's University Clinic for Ruminants in Vienna were analysed with respect to sheep and goat antibiotic doses administered over a 15-year period. Antibiotic use was assessed using total mg/kg, total milligrams, number of doses administered, Defined Daily Doses (nDDDvet) for cattle and estimated nDDD for sheep. Results: 5113 antibiotic doses were recorded over the 15-year period. Urinary tract disorders required the highest number of doses administered per animal (mean 16.9; median 16.0). Antibiotic use patterns varied according to the metrics used for analysis. By mg/kg, the largest proportion of antibiotics administered were penicillin/streptomycin (43.0% of the total mg/kg), followed by tetracyclines (17.3%) and sulfonamide/trimethoprim combinations (15.2%). By number of doses administered, the most frequently used antibiotics were penicillins (excluding combinations with streptomycin) (33.9% of total number of doses administered), fluoroquinolones (25.1%), 3rd/4th generation cephalosporins (13.6%) and penicillin/streptomycin (13.4%). Limitations: As the university clinic was a city-based referral centre, this analysis cannot be compared directly with antibiotic use in commercial herds or flocks. Conclusions: The considered choice of antibiotic use metrics is essential for an effective and meaningful analysis of the responsible use of antibiotics by veterinarians in practice.
Key words: doses; administered; antibiotic use; metrics; antibiotics; streptomyci提交时间：2023-01-01
版权声明：作者本人独立拥有该论文的版权，预印本系统仅拥有论文的永久保存权利。任何人未经允许不得重复使用。 -
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